Chromgen 02

A&S ChromgenTM

Supporting Hair
Follicle Pigmentation

From Exposome Stressors
to Stronger Color Vitality

A bio-responsive approach designed to support melanocyte-lineage signaling, melanin production, and healthier-looking hair color vitality.

Two-part pathway

  1. 1

    Follicle Stress Response

    Exposome factors
    ROS-associated inhibition

  2. 2

    Pigmentation Signaling

    Wnt / β-catenin and cAMP
    Melanin & color vitality

A&S Hair Science

Stressors Pigmentation

A&S Research & Development

01 · Exposome Factors & ROS

Hair Follicle Stressors

  • Stress /
    neurochemical surge

  • Oxidative stress / H2O2 accumulation

  • Nutritional deficiencies
    (B12, D3, Cu, Fe, Zn)

  • Hormonal / thyroid dysregulation

  • Autoimmune / chronic inflammatory responses

  • UV
    radiation

  • Air pollution / particulate matter
    (PM2.5)

  • Chemical dyes / harsh hair products

  • Tobacco smoke / vaping

  • Sleep / circadian disruption

Reactive oxygen species (ROS).ROS

Inhibits hair follicle

02 · Hair Follicle Pigmentation Signaling

Bio-Responsive Pigmentation Support

Scroll horizontally to explore the full signaling pathway.

Melanoblast and Wnt / beta-catenin signaling connect to melanocyte stem cells and follicular melanocytes. Follicular melanocytes connect to MITF and the alpha-MSH / MC1R / cAMP pathway. Chromgen supports secretion and signaling toward cAMP, which connects to MITF. MITF branches to tyrosinase and tyrosine, both connecting to melanin and then hair follicle pigmentation. The primary cilium is shown as a site of Wnt signaling.

Hair Follicle (Pigment Unit)

  1. Melanoblast
  2. Wnt / β-catenin
  3. Melanocyte stem cell (MSC) ↑
  4. Follicular melanocyte (FMC) ↑
  5. α-MSH ↑
  6. MC1R ↑
  7. cAMP ↑
  8. MITF ↑
  9. Tyrosinase ↑
  10. Tyrosine ↑
  11. Melanin ↑
  12. Hair Follicle Pigmentation ↑
Primary Cilia
Primary cilium on a melanocyte-lineage cell.
Wnt signaling occurs at the primary cilium of melanocyte lineage cells.

ChromgenTM supports
secretion / signaling

ChromgenTM

Proprietary bio-responsive
ingredient complex

stimulates
secretion /
signaling

Healthier Hair Color. Stronger Pigment Vitality.

Supports melanin-associated hair follicle pigmentation and healthier pigment cycling.

Chromgen 03

A&S ChromgenTM

Visible Hair
Color Benefits

From Pigmentation
Support to Color Vitality

A six-part benefit profile supporting visible hair color, follicle pigmentation, pigment-cell renewal, melanin biosynthesis, and a more vivid appearance.

A&S Hair Science

Six Visible Benefit
Directions

A&S Research & Development

A&S ChromgenTM · Visible Hair Benefit Profile

Six benefit areas reorganized into a concise two-row web layout.

Healthier-looking
hair color

Helps support visible pigment vitality and tone.

01 · Healthier hair color

Hair pigmentation
support

Supports melanin-associated hair follicle pigmentation.

02 · Pigmentation support

Color vitality

Supports a darker-looking, more vivid hair appearance.

03 · Color vitality

Follicular
melanocyte support

Helps support pigment-cell-associated renewal signaling.

04 · Melanocyte support

Melanin
biosynthesis

Supports melanin production pathways.

05 · Melanin biosynthesis

Reduced visible
dullness / early
gray appearance

Helps improve the appearance of pigment loss.

06 · Visible pigment loss

Hair Color · Pigmentation · Melanin Biosynthesis · Color Vitality