Cortiva 02

A&S CortivaTM

Modulating the
Skin Anti-Aging
Response

From Exposome Stressors
to Collagen & Wrinkle
Protection

A bio-responsive approach designed to help regulate acetylcholine and stress signaling, support dermal homeostasis, preserve collagen integrity, and reduce wrinkle formation.

Two-part pathway

  1. 1

    Epidermal Response

    Exposome stressors
    Acetylcholine modulation

  2. 2

    Dermal Response

    Stress & collagen signaling
    Visible anti-aging benefits

A&S Neuro-Skin Science

Stressors Response

Swipe to explore the complete pathways.

01 · Exposome Stressors & Epidermal Response

Exposome – Sensitive Skin Stressors

  • Heat
  • Chemicals
  • Microbes
  • UVB
  • Stress

Epidermis(Keratinocytes)

POMC
CortivaTMCortiva botanical leaf emblem
Inhibits
Acetylcholine (ACh)

Inhibits high acetylcholine
(ACh) levels

02 · Dermal Signaling & Visible Anti-Aging Benefits

Dermal Bio-Responsive Modulation

Dermis(Fibroblasts)

Two dermal fibroblast cells
Cortisol
Glucocorticoid receptor (GR)
MMP1
Fibroblast growth
IGF-1
Muscle contraction
Collagen
Parasympathetic

Reduced
collagen loss

Prevention of
wrinkle formation

CortivaTM — Visible Anti-Aging Benefits

  • Inhibits stress-induced
    cortisol activation
  • Improves dermal
    homeostasis
  • Reduces collagen
    degradation
  • Smooths wrinkles and
    enhances elasticity

A&S CortivaTM · Long-Term Skin Benefit Profile

Six benefit areas reorganized into a concise two-row web layout.

Shield with a leaf

Reduced Stress-Related Skin Sensitivity

Helps calm elevated acetylcholine (ACh) signaling for less reactive skin.

01 · SKIN SENSITIVITY

Balanced scales and signaling gears

Balanced Stress Signaling

Helps modulate stress-related skin responses for calmer skin balance.

02 · STRESS SIGNALING

Skin barrier protected by a shield

Stronger Dermal Homeostasis

Supports dermal balance and overall skin resilience.

03 · DERMAL HOMEOSTASIS

Collagen and skin structure

Reduced Collagen Loss

Helps preserve collagen and skin elasticity.

04 · COLLAGEN SUPPORT

Smoother skin with reduced wrinkles

Fewer Wrinkles & Fine Lines

Helps reduce wrinkle formation and improve smoothness.

05 · WRINKLE REDUCTION

Botanical shield representing resilient skin

Improved Skin Comfort & Resilience

Supports healthier-looking, more resilient skin over time.

06 · COMFORT & RESILIENCE

SKIN COMFORT · DERMAL HOMEOSTASIS · COLLAGEN PRESERVATION · WELL-BEING