01 · Exposome & Epidermal Response

Exposome – Skin Stressors

  • UV / UVB
  • Heat
  • Chemicals
  • Pollution
  • Microbiome
    dysbiosis
  • Stress

Epidermis (Keratinocytes)

TrevionTM Inhibits TRPV1 and TRPA1

TrevionTM
TRPV1Activity
TRPA1Activity

Strong Dual Inhibition

Keratinocyte
Response
(restored)

Neuroimmune Signals (Reduced)

  • Acetylcholine
    (ACh)
  • Histamine
  • Inflammatory
    cytokines

02 · Downstream Response & Barrier Integrity

Downstream Outcomes (Improved)

Skin inflammation
& neurogenic reactivity

Immune balance
& skin comfort

Stress Axis (Modulated)

cHPA Axis / Cortisol

Layered skin barrier supported by a protective shield.

Enhanced Skin Barrier Integrity

  • Stronger stratum corneum
  • Reduced permeability
  • Better barrier function
  • Resilient, healthy-looking skin
Compromised Barrier
Strengthened Barrier

Neuroimmune Signals · Downstream Outcomes · Stress Axis · Skin Barrier

TRPV1, transient receptor potential vanilloid 1; TRPA1, transient receptor potential ankyrin 1;
ACh, acetylcholine; cHPA, corticotropin–releasing hormone–pituitary–adrenal.

A&S Trevion™ · Long-Term Skin Benefit Profile

Six benefit areas organized into a concise two-row web layout.

Reduced
inflammation

Helps soothe and
calm reactive skin.

01 · Inflammation

Immune
balance

Supports a balanced
and adaptive skin
immune response.

02 · Immune Balance

Calmer skin

Helps reduce visible
redness and
sensitivity.

03 · Calmer Skin

Barrier
support

Strengthens skin
barrier for enhanced
protection.

04 · Barrier Support

Reduced stress-
related skin
discomfort

Helps buffer the impact
of stress on the skin.

05 · Stress-Related

Improved skin
comfort and
resilience

Promotes healthy-looking,
comfortable, and
resilient skin.

06 · Comfort & Resilience

Skin Comfort · Immune Balance · Barrier Resilience · Well-Being

Support-oriented benefit language retained from the supplied Trevion™ material.